Optineurin mediates negative regulation of Rab8 function by TBC1D17, a GTPase activating protein
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چکیده
منابع مشابه
E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy
The protein optineurin coded by OPTN gene is involved in several functions including regulation of endocytic trafficking, autophagy and signal transduction. Certain missense mutations in the gene OPTN cause normal tension glaucoma. A glaucoma-causing mutant of optineurin, E50K, induces death selectively in retinal cells. This mutant induces defective endocytic recycling of transferrin receptor ...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2012
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.102327